Application Type
Patent
Application SubType
National
(10) Registration Number and Date
BNN20200064 23.08.2021
Status
Registered
(180) Expiration Date
(20) Filing Number and Date
BN N/2020/0064 15.02.2019
(40) Publication Number and Date
BN N/2020/0064
A
23.08.2021
(86) PCT Filing Number and Date
(87) PCT Publication Number and Date
(85) National Entry Date
(30) Priority Details
US 62/671,576
15.05.2018
US 62/721,113
22.08.2018
US 62/631,659
17.02.2018
US 62/778,002
11.12.2018
(51) IPC Classes
(72) Inventor
(EN) MLYNARSKI, Scott Nathan
(EN) GREBE, Tyler
(EN) WANG, Jianyan
(EN) COOK, Steve
(74) Representative Name
(EN) Marks&Clerk Singapore LLP : Unit 404A-410A, 4th Floor, Wisma Jaya, Jalan Pemancha, Bandar Seri Begawan BS8811, Brunei Darussalam
(54) Title
(EN) ARGINASE INHIBITORS AND METHODS OF USE THEREOF
(57) Abstract
(EN)

Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase, wherein R1 is -NHR1a; R1a is -H or -C(O)CH(R1b)NHR1c; and R1b is selected from -H, -(C1-C4 ) alkyl and CH2OR1d and R1cis -H; or R1b and R1c, together with the atom to which they are attached, form a 5-membered heterocyclic ring; and R1d is H or -CH3.

(58) Citations
Document Type Date Action
Event NameDateStatus
Filing15.02.2019Filed
PCT National Phase Entry12.08.2020PCT National Phase
Registration23.08.2021Registered
Publication23.08.2021Published