Application Type
Patent
Application SubType
PCT National Phase
(10) Registration Number and Date
BNN20170044 02.12.2019
Status
Registered
(180) Expiration Date
(20) Filing Number and Date
BN N/2017/0044 30.11.2015
(40) Publication Number and Date
BN N/2017/0044
A
02.12.2019
(86) PCT Filing Number and Date
(87) PCT Publication Number and Date
(85) National Entry Date
(30) Priority Details
US 62/085,722
01.12.2014
US 62/166,808
27.05.2015
(71/73) Applicant
(72) Inventor
(EN) INGHARDT, Tord, Bertil
(EN) TOMKINSON, Nicholas
(EN) GAN, Li-Ming
(EN) JOHANNESSON, Petra
(EN) JURVA, Ulrik
(EN) MICHAËLSSON, Erik
(EN) LINDSTEDT-ALSTERMARK, Eva-Lotte
(74) Representative Name
(54) Title
(EN) 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE
(57) Abstract
(EN)
There are disclosed certain 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H- pyrrolo[3,2-d]pyrimidin-4-one compounds of formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of cardiovascular disorders such as heart failure and coronary artery disease related conditions.
(58) Citations