Application Type
Patent
Application SubType
PCT National Phase
(10) Registration Number and Date
BNN20180046 30.03.2023
Status
Registered
(180) Expiration Date
(20) Filing Number and Date
BN N/2018/0046 17.11.2016
(40) Publication Number and Date
BN N/2018/0046
A
30.03.2023
(86) PCT Filing Number and Date
(87) PCT Publication Number and Date
(85) National Entry Date
(30) Priority Details
US 62/257,001
18.11.2015
(72) Inventor
(EN) BUYSE, Marie-Ange
(EN) BOUTTON, Carlo
(EN) DOMBRECHT, Bruno
(EN) PUNNONEN, Juha
(EN) BEAUMONT, Maribel
(EN) VICTOR, Bjorn
(EN) KASTELEIN, Robert A.
(74) Representative Name
(EN) m/s Spruson & Ferguson Pte Ltd : C/O AIP Law Unit 404A-410A, 4th Floor, Wisma Jaya, Jalan Pemancha, Bandar Seri Begawan BS8811,
(54) Title
(EN) CTLA4 BINDERS
(57) Abstract
(EN)
The present invention provides molecules, such as ISVDs and Nanobodies, that bind to CTLA4 or human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
(58) Citations